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BREAST CANCER 1 GENE PRODUCT
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DeCS
Descriptor
English
:
BRCA1 Protein
Descriptor
Spanish
:
Proteína BRCA1
Descriptor
Portuguese
:
Proteína BRCA1
Synonyms
English
:
BRCA1 Gene Product
Breast Cancer 1 Gene Product
Breast Cancer 1 Protein
Breast Cancer Type 1 Susceptibility Protein
Ring Finger Protein 53
Tree Number:
D12.776.313.125
D12.776.624.776.100
D12.776.660.100
D12.776.744.100
D12.776.930.137
Definition
English
:
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING
FINGER
DOMAIN and is a
PROTEIN PHOSPHATASE 1
regulatory subunit. In normal cells the
BRCA1 protein
is localized in the nucleus, whereas in the majority of
breast
cancer cell lines and in malignant pleural effusions from
breast
cancer
patients
, it is localized mainly in the
cytoplasm
. (
Science
1995;270(5237):713,789-91)
See Related
English
:
Genes, BRCA1
Hereditary Breast and Ovarian Cancer Syndrome
History Note
English
:
97; was BRCA1 PROTEIN (NM) 1994-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33059
Unique Identifier:
D019313
Occurrence in VHL
:
Similar:
DeCS